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TRIZENONE DERIVATIVES

Examples of Commercial Product and Generic Names

Pharmacological Action or Site of Toxicity

Routes of Absorption

WHO Hazard Classification

Symptoms

Treatment

1. Antidote not known, symptomatic treatment is recommended.
2. Check blood pressure and pulse rate frequently since brady cardia and hypstonia are possible.
3. Supportive measures for re-enforcement of breathing and heart action. Give artificial respiratory if signs of Paralysis appear.
4. Additional therapeutic measures involve elimnation of the substances from the body acceleration of its excretion (gastrolavage, Saline laxatives).

5. On oral ingestion give plenty of water (no milk no alcohol) to drink, and a suspension of 10g or more of medical charcoal in 150-200 ml water.

   Take care before inducing vomiting (should be done if chemical swallowed is highly toxic and if medical assistance is not readily available), as there is a danger of aspiration of the solvent, with possible induction of pneumonid or pneumonitis.

   Only in fully conscious persons may vomiting be induced by stimulation of the back of the throat, e.g. with a finger tip.

   Give plenty of liquid to drink (several litres in the course of hours) to cause forced diuresis. If sodium bicarbonate is added to infusions follow the dosage instructions exactly because of the danger of respiratory depression.

6. Eyes:Open the eyelids with fingers and wash the conjunctiva with running water for several minutes or wash the conjunctiva with an appropriate eyewash device (e.g. plastic wash bottle filled with water).

7. Gastric lavage should only be carried out by a doctor and requires thepresence of 2 other qualified people. It is a measure indicated for all orally ingested life-threatening quantities of poison, even after earlier vomiting and in unconscious persons.

   In convulsions first inject 10 mg Diazepam (other banzodiazepine dervatives may also be used) intravenously as a apasmolytic, and to prevent vegal reflex also first administer 1 mg atropine, again by an i.v. Injection.

   The lavage itself should be carried out with watery suspension of activated charcoal if possible.

   Adults and children over 12 years: 50-100 g activated charcoal in every 300 to 800 ml of water (lukewarm).

   Children under 12 years: 50-30 g activated charcoal in every 100-300 ml of water (lukewarm).

   If activated charcoal is not available. the lavage may be carried out with lukewarm water alone.

8. If poisoning occurred via dermal route, skin and hair should be decontaminated.

Lab Test

Not applicable.

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Pakistan Agricultural Pesticides Association